Homocysteine is an amino acid that is closely concerned in a organic course of known as methylation. Throughout methylation, the bioactive type of folate (5-MTHF) donates a methyl group to homocysteine so it may be transformed into one other amino acid, methionine. When working optimally, methylation promotes cardiovascular, neurological, and reproductive well being; aids vitality manufacturing; bolsters detoxing pathways; helps longevity; and extra.
The issue is that greater than 50% of the U.S. inhabitants has a genetic mutation of the MTHFR gene that inhibits the physique’s capability to activate folate, so it could’t optimize methylation. If bioactive folate is not obtainable to assist convert homocysteine throughout the methylation cycle (i.e., as a consequence of an MTHFR gene variation or different causes—resembling poor weight-reduction plan, hormone imbalances, stress, or publicity to toxins), homocysteine ranges can turn out to be too excessive.
Elevated homocysteine ranges are linked to the next threat of power irritation, poor detoxing, heart problems, autoimmune situations, and sure—dementia.